abstract：:Arterial specimens were obtained from 12 patients during arterial repair surgery and 3 patients during nephrectomy following a bolus injection of autologous radio-iodinated very low density lipoprotein (VLDL) up to 30 h before surgery. Radioactivity in apoprotein B (apo B) was determined in lipoprotein fractions isola...

journal_title：Atherosclerosis

authors： Nicoll A,Duffield R,Lewis B

更新日期：1981-05-01 00:00:00

abstract：:Sixty-two subjects from 23 families were evaluated by serum lipid analyses and tissue culture biochemistry in skin fibroblasts. In 53 cases from 19 families with proven familial hypercholesterolemia (FHC), fibroblast cultures were successful. In 45 of these cases (85%) the clinical diagnosis of hyper- or normocholeste...

journal_title：Atherosclerosis

authors： Keller C,Harders-Spengel K,Spengel F,Wieczorek A,Wolfram G,Zöllner N

更新日期：1981-04-01 00:00:00

abstract：:The ultrastructural effects of a single brief intra-arterial infusion of palmitic, linoleic and acetoacetic acid on the arterial endothelium of the rat were investigated, and the following results obtained: (1) Palmitic acid, infused at a concentration of 4 mM/l, damaged the arterial lining by producing large cytoplas...

journal_title：Atherosclerosis

authors： Constantinides P,Kiser M

更新日期：1981-02-01 00:00:00

abstract：:Incubated human peripheral blood monocytes release a factor(s) which specifically stimulates homologous vascular smooth muscle (SMC) but not endothelial cells (EC) to proliferate in vitro. Conditioned medium from activated monocytes significantly (P less than 0.001) stimulated proliferation of SMC within 6 days of cul...

journal_title：Atherosclerosis

authors： Ziats NP,Robertson AL Jr

更新日期：1981-02-01 00:00:00

abstract：:The possible mechanisms of action of probucol on the metabolism of low density lipoprotein and of high density lipoprotein were studied in 5 hyperlipidaemic subjects. The kinetics of LDL-B protein and of HDL-AI protein were determined by 2-pool analysis of specific radioactivity-time curves after reinjection of 131I-l...

journal_title：Atherosclerosis

authors： Nestel PJ,Billington T

更新日期：1981-01-01 00:00:00

abstract：:Plasma apo B and apo A-I were determined in 477 subjects (206 males and 271 females) by laser immuno-nephelometry. Measurements of VLDL- + LDL-cholesterol, HDL-cholesterol and triglycerides were done simultaneously. VLDL- + LDL-cholesterol and apo B values were similar in males and females and increased with age. HDL-...

journal_title：Atherosclerosis

authors： Dedonder-Decoopman E,Fievet-Desreumaux C,Campos E,Moulin S,Dewailly P,Sezille G,Jaillard J

更新日期：1980-12-01 00:00:00

abstract：:The effects of niceritrol, a nicotinic acid derivative, on the levels of HDL-cholesterol (HDL-Ch) and a mixture of VLDL- and LDL-Ch (VLDL- + LDL-Ch) were studied in hyperlipidemic patients. Serum total cholesterol (sTC) and serum triglyceride (sTG) were significantly reduced during niceritrol administration. Lipoprote...

journal_title：Atherosclerosis

authors： Kibata M,Ishida M,Asano K,Uehara H,Saito K,Fuchimoto T,Ugaki K,Murakami H,Matoba K,Kotakemori Y,Shirai K,Yoshioka H,Nanba M,Yasuda M,Ishizaki M,Kitagawa N,Ikejiri K,Inohara R,Lee BJ,Saino S,Sakado J,Matuzaka H,

更新日期：1980-11-01 00:00:00

abstract：:Lack of physical activity appears to have deleterious effects on serum lipoproteins. Twenty-three patients who were completely immobilised by traumatic fracture of the spine had significantly lower (P < 0.001) plasma high density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I levels than normally mobile paired...

journal_title：Atherosclerosis

authors： Nikkilä EA,Kuusi T,Myllynen P

更新日期：1980-11-01 00:00:00

abstract：:This study was undertaken to determine whether sialic acid removal alters the catabolism of low density lipoprotein in humans. Human low density lipoproteins labeled in vitro with 125I were incubated in the presence (termed desialylated) or absence (sialylated) of neuraminidase. The treatment with neuraminidase from C...

journal_title：Atherosclerosis

authors： Malmendier CL,Delcroix C,Fontaine M

更新日期：1980-10-01 00:00:00

abstract：:Male adult New Zealand rabbits were fed a 2% cholesterol diet for 60 days followed by 10, 20, or 30 days of normal low cholesterol diet. Collagen synthesis was estimated by measuring aortic prolyl hydroxylase activity. Tissue cholesterol accumulation rates were estimated by dividing total tissue cholesterol by the num...

journal_title：Atherosclerosis

authors： Modrak JB,Langner RO

更新日期：1980-10-01 00:00:00

abstract：:Protein synthesis in smooth muscle cells from normal and atherosclerotic rabbit aortas was studied. Cultures of cells from the third passage were incubated with [3H]proline and the synthesis rates of collagen and total protein measured from the radioactivities incorporated into protein-bound hydroxyproline and proline...

journal_title：Atherosclerosis

authors： Pietilä K,Nikkari T

更新日期：1980-09-01 00:00:00

abstract：:The effect of 50 mg/kg body weight Xantinol-nicotinate (XN) on serum lipids and on non-esterified fatty acids (NEFA) was tested in 94 out-patients with hyperlipoproteinemia Types IIa, IIb, IV and V. The lipids were measured before treatment, during a 3-week period of drug administration and 10 days after rejection. In...

journal_title：Atherosclerosis

authors： Haacke H,Parwaresch MR,Mäder C

更新日期：1980-09-01 00:00:00

abstract：:KC-9432 (a new hypolipidemic compound, alpha-[p-(p-chlorobenzoyl) phenoxy-alpha-cyclohexyl acetic acid ethyl ester) was studied in rats for its effect on plasma lipid and lipoprotein levels. KC-9432 was particularly effective in hyperlipidemia in rats fed with a diet containing 2% cholesterol and 1% sodium cholate. Th...

journal_title：Atherosclerosis

authors： Seri K,Sato R,Hamazaki Y,Yamamoto T,Ishiyama N

更新日期：1980-09-01 00:00:00

abstract：:Serum total and HDL cholesterol concentrations were measured in schoolboy populations from 16 countries. Total and HDL cholesterol concentrations were determined in one laboratory to reduce methodological variability as much as possible. A standardized protocol was used for the drawing of blood, preparation, storage a...

journal_title：Atherosclerosis

authors： Knuiman JT,Hermus RJ,Hautvast JG

更新日期：1980-08-01 00:00:00

abstract：:To test the hypothesis of altered energy production in aortic sites predisposed to lesion formation, both coupled oxidative phosphorylation (evaluated from P/O ratios) and control of the energy-linked (ATP) NADH transhydrogenase were examined in muscular cushions at the celiac artery bifurcation. Comparisons were made...

journal_title：Atherosclerosis

authors： Hajjar DP,Smith SC

更新日期：1980-06-01 00:00:00

abstract：:The effect of chlorthalidone treatment on serum lipids and lipoproteins was investigated in 21 hypertensive patients. Chlorthalidone caused an increase in total serum and low density lipoprotein (LDL) cholesterol, but not in high density lipoprotein (HDL) cholesterol. Serum and lipoprotein triglycerides also increased...

journal_title：Atherosclerosis

authors： Rosenthal T,Holtzman E,Segal P

更新日期：1980-05-01 00:00:00

abstract：:Young pigs with hypertension of 10 weeks duration, resulting from cellophane perinephritis, were injected with 125I-labelled low-density lipoprotein ([125I]LDL) before being killed 24 h or 48 h later. Intimal thickening and increased acid mucopolysaccharide were demonstrated in the aortas and major arteries of the hyp...

journal_title：Atherosclerosis

authors： Sharpe DN,Scott PJ,Flint MH,Donald J

更新日期：1980-04-01 00:00:00

abstract：:Selected normal human arteries and veins were solubilized with detergents, neutral salt buffers and organic solvents. Comparative sodium dodecyl sulphate polyacrylamide gels and thin layer chromatographic plates were developed and the patterns compared. The low molecular weight periodic acid--Schiff positive band seen...

journal_title：Atherosclerosis

authors： Moore CR,Gilbert DB

更新日期：1980-03-01 00:00:00

abstract：:The topography of atherosclerotic lesions in the human basilar arteries has been studied quantitatively by digitizing images of the excised vessels and producing contour probability maps. Fifteen basilar arteries were obtained at autopsy (age--61 +/- 2; males--6, females--9; black--6, white--9), fixed in formalin, ope...

journal_title：Atherosclerosis

authors： Cornhill JF,Akins D,Hutson M,Chandler AB

更新日期：1980-01-01 00:00:00

abstract：:The serum concentrations of testosterone, androstenedione, oestradiol and total low polar oestrogens, mainly oestradiol and oestrone, were measured in 26 healthy male subjects. The subjects were divided into two groups each of them with low (less than 1.04 mmol/l) and high (greater than 1.56 mmol/l) levels of serum HD...

journal_title：Atherosclerosis

authors： Nordøy A,Aakvaag A,Thelle D

更新日期：1979-12-01 00:00:00

abstract：:In the abdominal aortas of young mash-fed swine, intimal cell masses (pads, cushions) are located predominantly away from blood vessel orifices. They are found scattered throughout the aorta but nevertheless have a definite pattern of distribution. In the distal one half of the abdominal aorta, they are more frequent ...

journal_title：Atherosclerosis

authors： Scott RF,Thomas WA,Lee WM,Reiner JM,Florentin RA

更新日期：1979-11-01 00:00:00

abstract：:The proliferation of aortic smooth muscle cells (ASMC) of Wistar rats, impaired by risk factors such as arterial hypertension, diabetes mellitus, atherogenic diet and staphylolysin injections and of normal Wistar rats treated with antirheumatic drugs such as prednisolone and acetylsalicylic acid was investigated. The ...

journal_title：Atherosclerosis

authors： Hauss WH,Mey J,Schulte H

更新日期：1979-10-01 00:00:00

abstract：:beta-Oxidation of long-chain fatty acids increases many-fold in atherosclerotic aortas; this may be due to an increase in the activity of the mitochondrial enzyme hexadecanoyl-CoA: carnitine O-hexadecanoyltransferase EC 2.3.1.23 (trivial name: carnitine palmitoyltransferase, CPT). To investigate this possibility, an a...

journal_title：Atherosclerosis

authors： Gillies PJ,Bell FP

更新日期：1979-09-01 00:00:00

abstract：:In vitro incubations of human low density lipoproteins (LDL), high density lipoproteins (HDL) and lipoprotein-free plasma at 37 degrees for 6 h revealed no significant net mass transfers of esterified cholesterol from either lipoprotein fraction to the other. Observed transfers of esterified [3H]cholesterol from LDL t...

journal_title：Atherosclerosis

authors： Barter PJ,Jones ME

更新日期：1979-09-01 00:00:00

abstract：:High density lipoprotein (HDL) was fractionated by ion exchange column chromatography using a continuous NaCl gradient of 0.06--0.13 M. It was found that, on the basic C apoprotein content, HDL is comprised of 3 subfractions. All 3 subfractions contain apo A-I and apo A-II but the apo A-I/apo A-II ratio is different i...

journal_title：Atherosclerosis

authors： Rubenstein B

更新日期：1979-08-01 00:00:00

abstract：:The fatty acid patterns of serum triglycerides and FFA in SHR and in normotensive controls aged 4, 8 and 26 weeks were estimated by gas-liquid chromatography. In serum triglycerides of SHR, the percentage of linoleic acid (C18:2) was lower and the content of arachidonic acid (C20:4) higher than in age-matched control ...

journal_title：Atherosclerosis

authors： Singer P,Voigt S,Moritz V,Baumann R

更新日期：1979-06-01 00:00:00

abstract：:Intact platelets from atherosclerotic rabbits release more thromboxane B2 (TXB2) and 12-hydroxyeicosatetraenoic acid (HETE) than platelets from normal rabbits following incubation with [14C]arachidonic acid (AA). In contrast, no difference is found between homogenates of platelets from normal and atherosclerotic anima...

journal_title：Atherosclerosis

authors： Dembińska-Kièć A,Rücker W,Schönhöfer PS

更新日期：1979-06-01 00:00:00

abstract：:The effect of administering blackgram (Phaseolus mungo) fiber (isolated as neutral detergent residue) at the 30% dietary level has been studied with regard to lipid concentration in the tissues and that of biliary and fecal bile acids and sterols. Rats were fed a high fat-cholesterol diet and compared with those fed a...

journal_title：Atherosclerosis

authors： Jayakumari N,Kurup PA

更新日期：1979-05-01 00:00:00

abstract：:The effect of immunological injury upon the early in vivo changes in aortic connective tissue metabolism was studied. It was found that a single antigen (bovine serum albumin), when administered in multiple doses, activated collagen synthesis and increased the rate of lgycosaminoglycan synthesis in the arterial wall. ...

journal_title：Atherosclerosis

authors： Rokosova B,Bentley JP

更新日期：1979-04-01 00:00:00

abstract：:ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase, significantly reduced both serum cholesterol and phospholipid levels in dogs, when used at a dosage higher than 10 mg/kg per day. Triglyceride levels were not consistently changed, but beta- and pre-beta-lipoproteins were preferentially redu...

journal_title：Atherosclerosis

authors： Tsujita Y,Kuroda M,Tanzawa K,Kitano N,Endo A

更新日期：1979-03-01 00:00:00

abstract：:The in vitro activity of cholesteryl ester hydrolase preparations of rat and rabbit aortas was assayed in the presence of the taurine and glycine conjugates of cholic, chenodeoxycholic, deoxycholic and lithocholic acids or in the presence of Triton X-100 and Tween-20. Maximum activity was obtained with tauro- or glyco...

journal_title：Atherosclerosis

authors： Kothari HV,Kritchevsky D

更新日期：1978-11-01 00:00:00

abstract：:The effects of platelet factors on human umbilical venous endothelial cell DNA-synthesis at various serum concentrations were studied. While [3H]thymidine uptake of these cells was almost linearly related to the concentration of serum in the culture medium, no significant differences were found at any serum level betw...

journal_title：Atherosclerosis

authors： Thorgeirsson G,Robertson AL Jr

更新日期：1978-10-01 00:00:00

abstract：:Plasmapheresis was studied as a means of reducing the serum cholesterol concentration in 3 hypercholesterolemic patients who each underwent courses of intensive plasmapheresis with removal of 250--500 ml of plasma each day for 5--9 days. In one homozygous Type II patient, the serum cholesterol concentration decreased ...

journal_title：Atherosclerosis

authors： Apstein CS,Zilversmit DB,Lees RS,George PK

更新日期：1978-10-01 00:00:00

abstract：:Men with ankylosing spondylitis (AS) and females with systemic lupus erythematosus (SLE) were found to have low total serum lipid concentrations similar to results previously obtained in patients with rheumatoid arthritis (RA). In AS men total serum TG was about 50% of control values and in AS men and SLE women total ...

journal_title：Atherosclerosis

authors： Rössner S

更新日期：1978-09-01 00:00:00

abstract：:Non-cholesterol-fed rabbits were exposed to carbon monoxide at concentrations in air of either 200, 2000, or 4000 parts per million (=0.02, 0.2 or 0.4%, vol/vol). Using the same criteria for intimal damage as in earlier morphological studies, no histotoxic effect on intimal/subintimal morphology of coronary arteries o...

journal_title：Atherosclerosis

authors： Hugod C,Hawkins LH,Kjeldsen K,Thomsen HK,Astrup P

更新日期：1978-08-01 00:00:00

abstract：:Detailed lipid composition of serum and isolated lipoprotein fractions in male and female transplant recipients has been determined. Results have been compared with appropriate controls and a number of abnormalities have become apparent: (i) Serum total cholesterol, triglyceride and phospholipid levels were significan...

journal_title：Atherosclerosis

authors： Abbott LK,Elliot C,Aitken JM,Somer JB

更新日期：1978-06-01 00:00:00

abstract：:The elevated carbon monoxide level found in tobacco smokers has been suggested as one etiologic factor linking it with atherosclerosis. Unquestionably carbon monoxide does induce some arterial wall hypoxia, which has been established as an atherogenic factor, but without knowing the extent and location of this hypoxia...

journal_title：Atherosclerosis

authors： Schneiderman G,Goldstick TK

更新日期：1978-05-01 00:00:00

abstract：:Lipoprotein-lipase activity (LPL) was measured in biopsies of adipose tissue and skeletal muscle of normal human subjects, and the results were related to concentrations of cholesterol and triglycerides in plasma lipoproteins. Adipose-tissue LPL activity was significantly higher in females than in males, whereas no se...

journal_title：Atherosclerosis

authors： Nikkilä EA,Taskinen MR,Kekki M

更新日期：1978-04-01 00:00:00

abstract：:The concentration of plasma fibrinogen increases with age and is particularly elevated in subjects with vascular changes due to atherosclerosis. Fibrinogen, which is the meeting point of the "cascade" of the coagulation factors and an important regulating factor of plasma viscosity, occupies a key position in atherosc...

journal_title：Atherosclerosis

authors： Pola P,Savi L

更新日期：1978-02-01 00:00:00

abstract：:An organ culture technique was used to investigate the removal of fatty acids incorporated into various lipid fractions in intimal segments of atherosclerotic rabbit aorta. Segments of aorta were pulse-labelled in vitro with [9,10-3H]oleic acid and [1-14C]linoleic acid for 24 h. The incubation medium was replaced with...

journal_title：Atherosclerosis

authors： Hudson K,Day AJ,Horsch AK

更新日期：1977-12-01 00:00:00